Gut-Liver Axis CRC1382

 

A06: A physiologically-based model of bile acid metabolism

This project aims to apply computational physiologically-based modelling of bile acid metabolism at the whole-body level to gain a more mechanistic understanding of its underlying processes. Models will be developed for the murine and human context and mechanistically describe synthesis, clearance and enterohepatic circulation of bile acids within the organism. Measurements of bile acid composition in various body fluids and profiling of the gut microbiota by 16S rRNA gene amplicon sequencing will be used to inform the mouse model. By doing so, the model can help to track alterations in bile acid levels and microbiota composition in response to therapeutic treatments. Informing the human model, clinical data of patients undergoing abdominal surgery, liver transplantation and transjugular intrahepatic portosystemic shunt (TIPS) procedure will be used. The computational model can then help to understand bile acid metabolism on a mechanistic level and aid in the identification of parameters relevant in the assessment of a patient’s risk for complications.

Staff: Bastian Kister

Further information: https://www.crc1382.org/a06/