Publikationen Lauterbach TUB



(33) Lorent L, Pelmenschikov V, Frielingsdorf S, Schoknecht J, Caserta G, Yoda Y, Wang H, Tamasaku K, Lenz O, Cramer SP, Horch M, § Lauterbach L, § Zebger I § 2021 Exploring structure and function of redox intermediates of [NiFe]-hydrogenases by an advanced experimental approach for solvated, lyophilized and crystallized metalloenzymes Angew. Chem. Int. Ed. 60,15854–15862 (Highlighted as front cover)

(32) Caserta G, Pelmenschikov V, Lorent C, Waffo AFT, Katz S, Lauterbach L, Schoknecht J, Wang H, Yoda Y, Tamasaku K, Kaupp M, Hildebrandt P, Lenz O, Cramer S.P. Zebger I § 2021 Hydroxy-bridged Resting States of [NiFe]-Hydrogenase Unraveled by Cryogenic Vibrational Spectroscopy and DFT Computations Chem. Sci. 12,2189–2197


(31) Al-Shameri A, Willot SJ-P, Paul CE, § Hollmann F, § Lauterbach L § 2020 H2 as a fuel for flavin- and H2O2-dependent biocatalytic reactions Chem. Commun. 56, 9667 - 9670

(30) Al-Shameri A, M Petrich M-C, Puring Kj, Apfel U-P, Nestl BM, Lauterbach L § 2020 Powering artificial enzymatic cascades with electrical energy Angew. Chem. Int. Ed. 59:10929–10933 (Highlighted as front cover)

(29) Preissler J, Reeve HA, Zhu T, Nicholson J, Urata K, Lauterbach L §, Wong LL, Vincent KA, § Lenz L§ 2020 Dihydrogen-driven NADPH recycling in imine reduction and P450-catalyzed oxidations mediated by an engineered O2-tolerant hydrogenase ChemCatChem (accepted)

(28) Schulz AC, Frielingsdorf S, Pommerening P, Lauterbach L, Bistoni G, Neese F, Oestreich M, Lenz O§ 2019 Formyltetrahydrofolate decarbonylase synthesizes the active site CO ligand of O2-tolerant [NiFe] hydrogenase. J Am Chem Soc. 142, 3, 1457-1464 (F1000 recommendation)


(27) Borlinghaus N, Weinmann L, Krimpzer F, Scheller PN, Al-Shameri A, Lauterbach L, Coquel A-S, Lattemann C, Hauer B, and Nestl BM, § Cascade biotransformation to access 3-methylpiperidine in whole cells ChemCatChem 11: 5738-5742

(26) Al-Shameri A, # Borlinghaus N, # Scheller P, Nestl BM, § Lauterbach L§ 2019 Synthesis of N-heterocycles from diamines via H2-driven NADPH recycling in the presence of O2. Green Chem 21: 1396-1400


(25) Lenz O, § Lauterbach L, Frielingsdorf S 2018 O2-tolerant [NiFe]-hydrogenases of Ralstonia eutropha H16: physiology, molecular Biology, purification, and biochemical analysis. In Enzymes of Energy Technology, Fraser Armstrong (Ed.), Methods in Enzymology, 613: 117-151

(24) Lauterbach L, § Lenz O 2018 How to make the reducing power of H2 available for in vivo biosyntheses and biotransformations. Curr Opin Chem Biol. 49:91-96 Review

(23) Preissler J, Wahlefeld S, Lorent C, Teutloff C, Horch M, § Lauterbach L, § Cramer SP, Zebger I, § Lenz O. § 2018 Enzymatic and spectroscopic properties of a thermostable [NiFe]‑hydrogenase performing H2-driven NAD+-reduction in the presence of O2. Biochim Biophys Acta. 1859: 8-18



(22) Gee, LB, Lin C-Y, Jenney, FE, Adams MWW, Yoda Y, Masuda R, Saito M, Kobayashi Y, Tamasaku K, Seto M, Riordan CG, Ploskonka A, Power PP, Cramer SP, § Lauterbach L 2016. Synchrotron-based nickel Mössbauer spectroscopy. Inorg. Chem. Inorg. Chem. 55: 6866–6872

(21) Lauterbach L,§ Gee, L, Pelmenschikov V, § Jenney FE, Kamali S,Yoda Y, Adams MWW, Cramer SP 2016 Characterization of the [3Fe–4S]0/1+ cluster from the D14C variant of Pyrococcus furiosus ferredoxin via combined NRVS and DFT analyses. Dalton Trans. 45:7215-7219


(20) Lonsdale T, # Lauterbach L, # Honda Malca S, Nestl BM, Hauer B, Lenz O § 2015 H2-driven biotransformation of n-octane to 1-octanol by a recombinant Pseudomonas putida strain co-synthesizing an O2-tolerant hydrogenase and a P450 monooxygenase Chem. Commun. 51:16173-16175 (highlighted as cover)

(19) Reeve HA, Lauterbach L, Lenz O, Vincent KA § 2015. Enzyme-modified particles for selective bio-catalytic hydrogenation via H2-driven NADH recycling, Chem. Cat. Chem. 7:3480-3487 (highlighted as cover)

(18) Löwenstein J, Lauterbach L, Teutloff C, Lenz O, Bittl R. § 2015. Active site of the NAD+-reducing hydrogenase from Ralstonia eutropha studied by EPR spectroscopy. J Phys. Chem. B. 119:13834-13841

(17) Holzer AK, Hiebler K, Mutti FG, Simon RC, Lauterbach L, Lenz O, Kroutil W. § 2015 Asymmetric biocatalytic amination of ketones at the expense of NH3 and molecular hydrogen, Org. Lett. 17:2431-2433

(16) Horch M, § Lauterbach L, Mroginski MA, Hildebrandt P, Lenz O, Zebger I. § 2015 Reversible active site sulfoxygenation can explain the oxygen tolerance of a NAD+-reducing [NiFe] hydrogenase and its unusual infrared spectroscopic properties, J. Am. Chem. Soc. 137:2555–2564

(15) Lauterbach L, #,§ Wang H, # Horch M, # Gee L B, Yoda Y, Tanaka Y, Zebger I, Lenz O, Cramer SP 2015. § Nuclear resonance vibrational spectroscopy reveals the FeS cluster composition and active site vibrational properties of an O2-tolerant NAD+ -reducing [NiFe] hydrogenase, Chem. Sci. 6:1055–1060

(14) Karstens K, Whlefeld S, Horch M, Grunzel M, Lauterbach L, Lendzian F, Zebger I, Lenz O. § 2015. Impact of the iron-sulfur cluster proximal to the active site on the catalytic function of an O2-tolerant NAD(+)-reducing [NiFe]-hydrogenase. Biochemistry. 54:389-403.



(13) Lauterbach L, Lenz O. § 2013 Catalytic water production by oxygen-tolerant [NiFe]-hydrogenase during H2 cycling in the presence of O2, J. Am. Chem. Soc. 135, 17897-17905.

(12) Herr N, Ratzka J, Lauterbach L, Lenz L, Ansorge-Schumacher § MB 2013 Stability enhancement of an O2-tolerant NAD+-reducing [NiFe]-hydrogenase by a combination of immobilisation und chemical modification, J. Mol. Catal B Enzym 97:169– 174

(11) Lauterbach L, Lenz O, Vincent K § 2013 H2-driven cofactor regeneration with NAD(P)+-reducing hydrogenases, FEBS Journal 280: 3058-3068. Review


(10) Ratzka J, Lauterbach L, Lenz O, Ansorge-Schumacher § M 2012 Stabilisation of the NAD+-reducing soluble [NiFe]-hydrogenase from Ralstonia eutropha H16 through modification with methoxy-poly(ethylene) glycol, J. Mol. Catal B Enzym 74:219– 223

(9) Reeve H, Lauterbach L, Ash P, Lenz O, Vincent K § 2012 A modular system for regeneration of NAD cofactors using graphite particles modified with hydrogenase and diaphorase moieties, Chem. Commun. 48:1589–1591

(8) Horch M, Lauterbach L, Lenz O, Hildebrandt P, Zebger I § 2012 NAD(H)-coupled hydrogen cycling – structure–function relationships of bidirectional [NiFe] hydrogenases FEBS Lett. 5:545–556


(7) Lauterbach L, Idris Z, Vincent KA, Lenz O § 2011 Catalytic properties of the isolated diaphorase fragment of the NAD+-reducing [NiFe]-hydrogenase from Ralstonia eutropha, PLoS ONE 6: e25939

(6) Lauterbach L, Liu J, Horch M, Hummel P, Schwarze A, Haumann M, Vincent KA, Lenz L, Zebger I. § 2011 The hydrogenase subcomplex of the NAD+-reducing [NiFe]-hydrogenase from Ralstonia eutropha- insights into catalysis and redox interconversions Eur. J. Inorg. Chem. 1067-1079

(5) Ratzka J, Lauterbach L, Lenz O, Ansorge-Schumacher M § 2011 Systematic evaluation of the dihydrogen oxidising and NAD+-reducing soluble [NiFe]- hydrogenase from Ralstonia eutropha H16 as a cofactor regeneration catalyst Biocat.& Biotrans. 29:246-252

(4) Wahl M, § Link H, Alexandridis N, Thomason JC, Cifuentes M, Costello MJ, da Gama BA, Hillock K, Hobday AJ, Kaufmann MJ, Keller S, Kraufvelin P, Krüger I, Lauterbach L, Antunes BL, Molis M, Nakaoka M, Nyström J, bin Radzi Z, Stockhausen B, Thiel M, Vance T, Weseloh A, Whittle M, Wiesmann L, Wunderer L, Yamakita T, Lenz M. 2011 Re-structuring of marine communities exposed to environmental change: a global study on the interactive effects of species and functional richness. PLoS One. 6(5):e19514 (F1000 recommendation)


(3b) Horch M, # Lauterbach L, # Saggu M, # Hildebrandt P, Lendzian, Bittl R, Lenz O and Zebger I. § 2010 Probing the active site of an O2-tolerant NAD+-reducing [NiFe]- hydrogenase from Ralstonia eutropha H16 by in situ EPR and FTIR Spectroscopy, Angew. Chem. Int. Ed. 49, 8026-8029

(3a) Horch M,# Lauterbach L,# Saggu M, # Hildebrandt P, Lendzian, Bittl R, Lenz O and Zebger I. § 2010 Untersuchung des katalytischen Zentrums der O2-toleranten NAD+- reduzierenden [NiFe]-Hydrogenase von Ralstonia eutropha H16 mit In-situ-EPR- und -FTIR-Spektroskopie Angew. Chemie 43, 8200–8203


(2) Tsoi BM, Beckhouse AG, Gelling CL, Raftery MJ, Chiu J, Tsoi AM, Lauterbach L, Rogers PJ, Higgins VJ, Dawes IW. § 2009 Essential role of one-carbon metabolism and GCN4P and BAS1P transcriptional regulators during adaptation to anaerobic growth of Saccharomyces cerevisiae. JBC 17: 11205–11215 (F1000 recommendation)


(1) Vance T, § Lauterbach L, Lenz M, Wahl M, Sanderson RA, Thomason JC. 2008 Rapid invasion and ecological interactions of Diplosoma listerianum in the North Sea, UK. JMBA2 doi:10.1017/S1755267209000815


Vincent KA, Lauterbach L, Lenz O, Cofactor regeneration system, WO20130760 A2

Vincent KA, Reeve H, Rowbotham J, Lent O, Lauterbach L, Lonsdale T, Huang A, Cofactor labelling with hydrogen isotopes PCT/EP2019/053447


Lenz O, Lauterbach L, Frielingsdorf S, Friedrich B 2014 Oxygen-tolerant hydrogenases and their biotechnological potential. In Biohydrogen, Matthias Rögner (Ed.), De Gruyter ISBN 978-3-11-033645-0.

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