Publications

Showing 1 - 19 of 19 Results

  • Title
    Author(s)
    Details
  • A 3D Heterotypic Multicellular Tumor Spheroid Assay Platform to Discriminate Drug Effects on Stroma versus Cancer Cells
    SLAS discovery 12, 247255521988019 (2019)
    Weydert, Zoe
    Lal-Nag, Madhu
    Mathews-Greiner, Lesley
    Thiel, Christoph Werner Josef
    Cordes, Henrik
    et al.
    Details
  • A Physiology-Based Model of Human Bile Acid Metabolism for Predicting Bile Acid Tissue Levels After Drug Administration in Healthy Subjects and BRIC Type 2 Patients
    Frontiers in physiology 10, 1192 (2019)
    Baier, Vanessa
    Cordes, Henrik
    Thiel, Christoph
    Castell, José V.
    Neumann, Ulf P.
    et al.
    Details
  • A physiology-based model of bile acid metabolism shows altered tissue concentrations after drug administration and in specific genotype subgroups, 28 Seiten (2018)
    Baier, Vanessa
    Cordes, Henrik
    Thiel, Christoph Werner Josef
    Neumann, Ulf P.
    Blank, Lars M.
    et al.
    Details
  • Using quantitative systems pharmacology to evaluate the drug efficacy of COX-2 and 5-LOX inhibitors in therapeutic situations
    npj Systems biology and applications 4, 28 (2018)
    Thiel, Christoph Werner Josef
    Smit, Ines
    Baier, Vanessa
    Cordes, Henrik
    Fabry, Brigida
    et al.
    Details
  • Integration of genome-scale metabolic networks into whole-body PBPK models shows phenotype-specific cases of drug-induced metabolic perturbation
    npj Systems biology and applications 4, 10 (2018)
    Cordes, Henrik
    Thiel, Christoph Werner Josef
    Baier, Vanessa
    Blank, Lars M.
    Küpfer, Lars
    Details
  • A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity
    Archives of toxicology 92, 553-555 (2017)
    Küpfer, Lars
    Clayton, Olivia
    Thiel, Christoph Werner Josef
    Cordes, Henrik
    Nudischer, Ramona
    et al.
    Details
  • Modeling the influence of valproic acid on endogenous metabolite levels in human blood, 1 Online-Ressource (74 Seiten) : Illustrationen (2017)
    Gubicza, Krisztina
    Details
  • Towards knowledge-driven cross-species extrapolation
    Drug discovery today / Disease models 22, 21-26 (2016)
    Thiel, Christoph Werner Josef
    Hofmann, Ute
    Ghallab, Ahmed
    Gebhardt, Rolf
    Hengstler, Jan G.
    et al.
    Details
  • A Comparative Analysis of Drug-Induced Hepatotoxicity in Clinically Relevant Situations
    PLoS Computational Biology 13, e1005280 (2017)
    Thiel, Christoph Werner Josef
    Cordes, Henrik
    Fabbri, Lorenzo
    Aschmann, Hélène Eloise
    Baier, Vanessa
    et al.
    Details
  • Multiscale modeling reveals inhibitory and stimulatory effects of caffeine on acetaminophen-induced toxicity in humans
    CPT: pharmacometrics & systems pharmacology 6, 136-146 (2017)
    Thiel, Christoph Werner Josef
    Cordes, Henrik
    Baier, Vanessa
    Blank, Lars M.
    Küpfer, Lars
    Details
  • Model-based contextualization of in vitro toxicity data quantitatively predicts in vivo drug response in patients
    Archives of toxicology 91, 865-883 (2016)
    Thiel, Christoph Werner Josef
    Cordes, Henrik
    Conde, Isabel
    Castell, José Vicente
    Blank, Lars M.
    et al.
    Details
  • A Physiologically Based Pharmacokinetic Model of Isoniazid and Its Application in Individualizing Tuberculosis Chemotherapy
    Antimicrobial agents and chemotherapy : AAC 60, 6134-6145 (2016)
    Cordes, Henrik
    Thiel, Christoph Werner Josef
    Aschmann, Hélène E.
    Baier, Vanessa
    Blank, Lars M.
    et al.
    Details
  • Impact of NAT2 Phenotype on Early Bactericidal Activity of Isoniazid Predicted by PBPK/PD Modeling, 108 S. (2015)
    Aschmann, Hélène Eloise
    Cordes, Henrik
    Küpfer, Lars
    Blank, Lars Mathias
    Details
  • A Systematic Evaluation of the Use of Physiologically Based Pharmacokinetic Modeling for Cross-Species Extrapolation
    Journal of pharmaceutical sciences 104, 191-206 (2015)
    Thiel, Christoph Werner Josef
    Schneckener, Sebastian
    Krauss, Markus
    Ghallab, Ahmed
    Hofmann, Ute
    et al.
    Details
  • The virtual liver: state of the art and future perspectives
    Archives of toxicology 88, 2071-2075 (2014)
    Drasdo, Dirk
    Bode, Johannes
    Dahmen, Uta
    Dirsch, Olaf
    Dooley, Steven
    et al.
    Details
  • Spatio-Temporal Simulation of First Pass Drug Perfusion in the Liver
    PLoS computational biology 10, e1003499 (2014)
    Schwen, Lars Ole
    Krauss, Markus
    Niederalt, Christoph
    Gremse, Felix
    Kießling, Fabian
    et al.
    Details
  • Enabling multiscale modeling in systems medicine
    Genome medicine 6, 21 (2014)
    Wolkenhauer, Olaf
    Auffray, Charles
    Brass, Olivier
    Clairambault, Jean
    Deutsch, Andreas
    et al.
    Details
  • Modellierung metabolischer Netzwerke im menschlichen Körper
    Biospektrum : das Magazin für Biowissenschaften 20, 39-41 (2014)
    Cordes, Henrik
    Thiel, Christoph Werner Josef
    Blank, Lars M.
    Küpfer, Lars
    Details
  • Integrating Cellular Metabolism into a Multiscale Whole-Body Model
    PLoS computational biology 8, e1002750 (2012)
    Krauss, Markus
    Schaller, Stephan
    Borchers, Steffen
    Findeisen, Rolf
    Lippert, Jörg
    et al.
    Details